ACLY Polyclonal Antibody Store at -20°C

ACLY Polyclonal Antibody Store at -20°C SKU # E-AB-10986 Reactivity Human, Mouse, Rat Host Rabbit Applications IHC Product Details Isotype IgG Host Rabbit Reactivity Human,  Mouse,  Rat Applications IHC Clonality Polyclonal Immunogen Recombinant protein of human ACLY Abbre ACLY Synonyms ACL,  ACLY,  ATP citrate (pro-S) lyase,  ATP citrate lyase,  ATP citrate synthase,  ATP-citrate (pro-S-)-lyase,  ATP-citrate synthase,  ATPCL,  ATPcitrate synthase,  Acly,  CLATP,  Citrate cleavage enzyme,  OTTHUMP00000164773 Swissprot P53396 Cellular Localization Cytoplasm. Concentration 0.4 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Cancer,  Metabolism,  Signal Transduction Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution IHC 1:50-1:200 Background ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene.