IRAK1BP1 Polyclonal Antibody Store at -20°C

IRAK1BP1 Polyclonal Antibody Store at -20°C SKU # E-AB-10411 Reactivity Human, Mouse Host Rabbit Applications WB, IHC Product Details Isotype IgG Host Rabbit Reactivity Human,  Mouse Applications WB,  IHC Clonality Polyclonal Immunogen Recombinant protein of human IRAK1BP1 Abbre IRAK1BP1 Synonyms AIP70,  ActA binding protein 3,  IRAK1-binding protein 1,  Interleukin 1 receptor associated kinase 1 binding protein 1,  SIMPL,  Signaling molecule that associates with Pelle-like kinase Swissprot Q5VVH5 Calculated MW 29 kDa Cellular Localization Cytoplasmic and Nuclear. Concentration 0.4 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Immunology,  Signal Transduction Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution WB 1:500-1:2000 IHC 1:50-1:200 Background SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active..