LILRB1 Polyclonal Antibody

LILRB1 Polyclonal Antibody SKU # E-AB-10412 Reactivity Human Host Rabbit Applications IHC Product Details Isotype IgG Host Rabbit Reactivity Human Applications IHC Clonality Polyclonal Immunogen Recombinant protein of human LILRB1 Abbre LILRB1 Synonyms CD85,  CD85 antigen,  CD85 antigen like family member J,  CD85 antigen-like family member J,  CD85j,  CD85j antigen,  ILT 2,  ILT-2,  ILT2,  Ig like transcript 2,  Immunoglobulin-like transcript 2,  Leukocyte immuno,  immunoglobulin like transcript 2,  leukocyte Ig like receptor 1 Swissprot Q8NHL6 Cellular Localization Membrane. Concentration 0.3 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Immunology Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution IHC 1:50-1:200 Background This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene..