MPG Polyclonal Antibody Store at -20°C

MPG Polyclonal Antibody Store at -20°C SKU # E-AB-10980 Reactivity Human Host Rabbit Applications WB, IHC Product Details Isotype IgG Host Rabbit Reactivity Human Applications WB, IHC Clonality Polyclonal Immunogen Recombinant protein of human MPG Abbre MPG Synonyms 3 alkyladenine DNA glycosylase,  3-alkyladenine DNA glycosylase,  3-methyladenine DNA glycosidase,  3MG,  AAG,  ADPG,  APNG,  Alkyladenine DNA glycosylase,  CRA36.1,  DNA 3 methyladenine glycosylase,  DNA-3-methyladenine glycosylase,  MDG,  Mid1,  Mpg,  N methylpurine DNA glyco,  anpg Swissprot P29372 Calculated MW 32 kDa Cellular Localization Nucleus. Concentration 0.5 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Epigenetics and Nuclear Signaling Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution WB 1:1000-1:5000 IHC 1:50-1:200 Background Maintenance of DNA sequences is necessary for vertebrates and other life.DNA is under constant stress by a plethora of DNA-damaging agents present in both the environment and within cells.The potentially deleterious effects of DNA lesions in cells are elegantly resolved by sophisticated DNA repair systems, including base excision repair (BER), nucleotide excision repair (NER) and DNA repair methyltransferase (MTase).Methylated bases, such as 3-methyladenine (3MeA) and 7-methylguanine (7MeG) can be formed by agents in the environment and by endogenous cellular processes.Consequently, in the absence of exposure to environmental agents, DNA methylation damage can be incurred on the genomic DNA of normal mammalian cells.DNA N-glycosylases are base excision-repair proteins that locate and cleave damaged bases from DNA as the first step in restoring the sequence.