PTCH1 Polyclonal Antibody Reactivity Human, Mouse

PTCH1 Polyclonal Antibody Reactivity Human, Mouse SKU # E-AB-10571 Reactivity Human, Mouse Host Rabbit Applications WB, IHC Product Details Isotype IgG Host Rabbit Reactivity Human,  Mouse Applications WB,  IHC Clonality Polyclonal Immunogen Recombinant protein of human PTCH1 Abbre PTCH1 Synonyms BCNS,  HPE7,  NBCCS,  PTC,  PTC1,  PTCH,  PTCH11 Swissprot Q13635 Calculated MW 161 kDa Cellular Localization Nucleus, Plasma Membrane, caveola, ciliary membrane, plasma membrane, Other locations: axonal growth cone, dendritic growth cone, endocytic vesicle membrane, integral component of membrane, intracellular membrane-bounded organelle, midbody, perinuclear region of cytoplasm, postsynaptic density. Concentration 0.5 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Cancer,  Cell Biology,  Neuroscience,  Stem Cells Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution WB 1:500-1:2000 IHC 1:50-1:200 Background This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.