RARA Polyclonal Antibody

RARA Polyclonal Antibody SKU # E-AB-10577 Reactivity Human, Mouse Host Rabbit Applications IHC Product Details Isotype IgG Host Rabbit Reactivity Human,  Mouse Applications IHC Clonality Polyclonal Immunogen Recombinant protein of human RARA Abbre RARA Synonyms NR1B1,  Nuclear mitotic apparatus protein retinoic acid receptor alpha fusion protein,  Nuclear receptor subfamily 1 group B member 1,  Nucleophosmin retinoic acid receptor alpha fusion protein NPM RAR long form,  RAR,  RAR alpha,  RAR-alpha,  RARA,  RARalp,  RARalpha,  rara Swissprot P10276 Cellular Localization Nucleus. Cytoplasm. Nuclear localization depends on ligand binding, phosphorylation and sumoylation. Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation. Concentration 0.3 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Cancer,  Epigenetics and Nuclear Signaling,  Signal Transduction Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution IHC 1:50-1:200 Background This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.