ITGB3BP Polyclonal Antibody Store at -20°C

ITGB3BP Polyclonal Antibody Store at -20°C SKU # E-AB-10402 Reactivity Human Host Rabbit Applications IHC Product Details Isotype IgG Host Rabbit Reactivity Human Applications IHC Clonality Polyclonal Immunogen Recombinant protein of human ITGB3BP Abbre ITGB3BP Synonyms Beta 3 endonexin,  Beta-3,  Beta3 endonexin,  Beta3 endonexin long form,  CENP R,  CENPR,  Centromere protein R,  HSU37139,  Integrin beta 3 binding protein,  Integrin beta 3 binding protein (beta3-endonexin),  NRIF 3,  NRIF3,  Nuclear receptor interacting factor,  endonexin Swissprot Q13352 Cellular Localization Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Cytoplasm. Isoform 4: Cytoplasm. Note=Localizes in the centromeres. Isoform 3 is predominantly nuclear and weakly cytoplasmic. Concentration 0.7 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Epigenetics and Nuclear Signaling,  Signal Transduction Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution IHC 1:50-1:200 Background This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.