CABLES1 Polyclonal Antibody

CABLES1 Polyclonal Antibody SKU # E-AB-11017 Reactivity Human, Mouse Host Rabbit Applications WB Product Details Isotype IgG Host Rabbit Reactivity Human,  Mouse Applications WB Clonality Polyclonal Immunogen Recombinant protein of human CABLES1 Abbre CABLES1 Synonyms CABL1,  CABLES,  CDK5 and ABL1 enzyme substrate 1,  Cables1,  Cdk5 and Abl enzyme substrate 1,  FLJ35924,  HsT2563,  IK3 1,  Ik3-1,  Interactor with CDK3 1 Swissprot Q8TDN4 Calculated MW 68 kDa Cellular Localization Nucleus. Cytoplasm. Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons. Concentration 0.4 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Cancer,  Cell Biology Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution WB 1:500-1:2000 Background This gene encodes a protein involved in regulation of the cell cycle through interactions with several cyclin-dependent kinases. One study (PMID: 16177568) reported aberrant splicing of transcripts from this gene which results in removal of the cyclin binding domain only in human cancer cells, and reduction in gene expression was shown in colorectal cancers (PMID: 17982127).Multiple transcript variants encoding different isoforms have been found for this gene.