BAIAP2 Polyclonal Antibody Store at -20°C

BAIAP2 Polyclonal Antibody Store at -20°C SKU # E-AB-10414 Reactivity Human, Mouse, Rat Host Rabbit Applications IHC Product Details Isotype IgG Host Rabbit Reactivity Human,  Mouse,  Rat Applications IHC Clonality Polyclonal Immunogen Recombinant protein of human BAIAP2 Abbre BAIAP2 Synonyms BAI-associated protein 2,  BAI1 associated protein 2,  BAI1-associated protein 2,  BAIAP 2,  BAIP2,  BAP2,  Baiap2,  Brain-specific angiogenesis inhibitor 1-associated protein 2,  FLAF3,  Fas ligand-associated factor 3,  Insulin receptor substr,  Insulin receptor substrate p53 Swissprot Q9UQB8 Cellular Localization Cytoplasm. Membrane. Cell projection>filopodium. Cell projection>ruffle. Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Concentration 0.2 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Neuroscience Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution IHC 1:50-1:200 Background The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.