SPDEF Polyclonal Antibody

SPDEF Polyclonal Antibody SKU # E-AB-10535 Reactivity Human, Mouse Host Rabbit Applications IHC Product Details Isotype IgG Host Rabbit Reactivity Human,  Mouse Applications IHC Clonality Polyclonal Immunogen Recombinant protein of human SPDEF Abbre SPDEF Synonyms PDEF,  PROSTATE EPITHELIUM SPECIFIC ETS TRANSCRIPTION FACTOR,  PSE,  Prostate derived Ets factor,  Prostate epithelium-specific Ets transcription factor,  Prostate specific Ets,  Prostate-derived Ets factor,  Prostate-specific Ets,  RP11-375E1__A.3,  SAM POINTED ,  bA375E1.3 Swissprot O95238 Cellular Localization Nucleus. Concentration 1 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Cancer,  Epigenetics and Nuclear Signaling Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution IHC 1:50-1:200 Background The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.