CDKN2AIP Polyclonal Antibody Store at -20°C

CDKN2AIP Polyclonal Antibody Store at -20°C SKU # E-AB-10510 Reactivity Human Host Rabbit Applications IHC Product Details Isotype IgG Host Rabbit Reactivity Human Applications IHC Clonality Polyclonal Immunogen Recombinant protein of human CDKN2AIP Abbre CDKN2AIP Synonyms CARF,  CDKN2A interacting protein,  CDKN2A-interacting protein,  Calcium response factor,  Cdkn2aip,  Collaborator of ARF,  FLJ20036,  collaborates/cooperates with ARF (alternate reading frame) protein Swissprot Q9NXV6 Cellular Localization Nucleus>nucleoplasm. Concentration 0.3 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Cancer,  Cell Biology,  Epigenetics and Nuclear Signaling Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution IHC 1:50-1:200 Background CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.