FLT3 Polyclonal Antibody Store at -20°C

FLT3 Polyclonal Antibody Store at -20°C SKU # E-AB-10844 Reactivity Human,  Mouse Host Rabbit Applications IHC Product Details Isotype IgG Host Rabbit Reactivity Human,  Mouse Applications IHC Clonality Polyclonal Immunogen Recombinant protein of human FLT3 Abbre FLT3 Synonyms CD 135,  CD135,  CD135 antigen,  FL cytokine receptor,  FLT-3,  FLT3,  FMS like tyrosine kinase 3,  Fetal liver kinase 2,  Flk 2,  Flk2,  Flt 3,  Flt3,  Fms related tyrosine kinase 3,  Fms-like tyrosine kinase 3,  Growth factor receptor tyrosine kinase type III,  Ly-72,  OTTHUMP00000042 Swissprot P36888 Cellular Localization Membrane. Concentration 0.5 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Immunology,  Signal Transduction Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution IHC 1:50-1:200 Background This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.