MVP Polyclonal Antibody Store at -20°C

MVP Polyclonal Antibody Store at -20°C SKU # E-AB-10434 Reactivity Human, Mouse, Rat Host Rabbit Applications WB, IHC Product Details Isotype IgG Host Rabbit Reactivity Human,  Mouse,  Rat Applications WB,  IHC Clonality Polyclonal Immunogen Recombinant protein of human MVP Abbre MVP Synonyms LRP,  Lung resistance related protein,  Lung resistance-related protein,  MVP,  Major vault protein,  VAULT 1,  VAULT1,  homolog of,  rat,  testicular secretory protein Li 30 Swissprot Q14764 Calculated MW 99 kDa Cellular Localization Cytoplasm. Nucleus>nuclear pore complex. 5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment. Concentration 0.3 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Cancer,  Signal Transduction Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution WB 1:500-1:2000 IHC 1:50-1:200 Background This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene.