NANOS2 Polyclonal Antibody

NANOS2 Polyclonal Antibody SKU # E-AB-11419 Reactivity Human Host Rabbit Applications IHC Product Details Isotype IgG Host Rabbit Reactivity Human Applications IHC Clonality Polyclonal Immunogen Recombinant protein of human NANOS2 Abbre NANOS2 Synonyms NANO2,  NANOS2,  NOS-2,  NOS2,  Nanos homolog 2,  Nanos homolog 2 Drosophila Swissprot P60321 Cellular Localization Cytoplasm. Cytoplasm>P-body. Cytoplasm>perinuclear region. Localizes at P-bodies during gonocyte development (By similarity). More abundant in perinuclear region of the cytoplasm of the germ cells of the adult testis. Concentration 0.3 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Epigenetics and Nuclear Signaling,  Developmental Biology,  Stem Cells Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution IHC 1:50-1:200 Background Nanos2, also known as NOS2, is a 138 amino acid protein that contains one nanos-type zinc finger.The nanos-type zinc finger is comprised of two C2HC motifs, each of which are capable of binding one molecule of zinc and each of which work in tandem to play essential roles in translational regulation events.Expressed specifically in male germ cells, Nanos2 is essential for spermatogonia formation and is required to support the self-renewal, proliferation and overall development of proximal germ cells.Additionally, Nanos2 is thought to regulate the translation of target mRNAs, possibly by associating with the 3’-UTR of select transcripts.