ALKBH1 Polyclonal Antibody

ALKBH1 Polyclonal Antibody SKU # E-AB-10699 Reactivity Human, Mouse Host Rabbit Applications WB Product Details Isotype IgG Host Rabbit Reactivity Human,  Mouse Applications WB Clonality Polyclonal Immunogen Recombinant protein of human ALKBH1 Abbre ALKBH1 Synonyms ABH,  ABH1,  ALKB1,  ALKBH,  ALKBH1,  AlkB,  Alkylated DNA repair protein alkB homolog 1,  Alkylation repair,  Alkylation repair homolog 1,  Alpha-ketoglutarate-dependent dioxyge,  alkB,  alkB homolog,  alkB homolog 1 histone H2A dioxygenase,  alkylation repair homolog 1 (E. coli) Swissprot Q13686 Calculated MW 44 kDa Cellular Localization Mitochondrion. Nucleus. Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli. Concentration 0.3 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Cancer,  Epigenetics and Nuclear Signaling Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution WB 1:500-1:2000 Background This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites.