COPS5 Polyclonal Antibody Store at -20°C

COPS5 Polyclonal Antibody Store at -20°C SKU # E-AB-10415 Reactivity Human, Mouse Host Rabbit Applications WB, IHC Product Details Isotype IgG Host Rabbit Reactivity Human,  Mouse Applications WB,  IHC Clonality Polyclonal Immunogen Recombinant protein of human COPS5 Abbre COPS5 Synonyms 38 kDa Mov34 homolog,  COP9 (constitutive photomorphogenic) homolog subunit 5,  COP9 constitutive photomorphogenic homolog subunit 5,  COP9 signalosome complex subunit 5,  COP9 signalosome subunit 5,  COPS 5,  CSN 5,  CSN5,  Cop9 subunit 5,  JAB 1,  Jun activation,  cops5 Swissprot Q92905 Calculated MW 38 kDa Cellular Localization Cytoplasm. Nucleus. Concentration 0.9 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Cancer,  Cell Biology,  Epigenetics and Nuclear Signaling,  Neuroscience,  Signal Transduction Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution WB 1:1000-1:5000 IHC 1:150-1:500 Background The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.