CTNNA1 Polyclonal Antibody

CTNNA1 Polyclonal Antibody SKU # E-AB-10207 Reactivity Human, Mouse Host Rabbit Applications WB, IHC Product Details Isotype IgG Host Rabbit Reactivity Human,  Mouse Applications WB,  IHC Clonality Polyclonal Immunogen Recombinant protein of human CTNNA1 Abbre CTNNA1 Synonyms 102kDa,  Alpha E-catenin,  CAP 102,  CAP102,  Cadherin associated protein,  Cadherin associated protein 102kDa,  Cadherin-associated protein,  Catenin (cadherin associated protein),  Catenin (cadherin associated protein) alpha 1 102kDa,  Catenin alp,  Catenin alpha 1,  alpha 1 Swissprot P35221 Calculated MW 100 kDa Cellular Localization Cell membrane and Cytoplasm>cytoskeleton. Cell junction>adherens junction. Cell membrane. Cell junction. Found at cell-cell boundaries and probably at cell-matrix boundaries. Concentration 0.2 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Cancer,  Signal Transduction,  Stem Cells Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution WB 1:500-1:2000 IHC 1:50-1:200 Background Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene.Associates with the cytoplasmic domain of a variety of cadherins.The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties.Can associate with both E- and N-cadherins.Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions.In contrast, cortical actin was found to be mucHuman, Mouseore dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components.