pVHL Polyclonal Antibody

pVHL Polyclonal Antibody SKU # E-AB-10671 Reactivity Human Host Rabbit Applications IHC Product Details Isotype IgG Host Rabbit Reactivity Human Applications IHC Clonality Polyclonal Immunogen Recombinant protein of human VHL Abbre pVHL Synonyms E3 ubiquitin pro,  Elongin binding protein,  G7 protein,  HRCA 1,  HRCA1,  Protein G7,  RCA 1,  RCA1,  VHL,  VHL 1,  VHL1,  VHLH,  Von Hippel Lindau disease tumor suppressor,  Von Hippel Lindau tumor suppressor,  pVHL,  von Hippel Lindau syndrome,  von Hippel Lindau tumor suppressor Swissprot P40337 Cellular Localization Cytoplasm, Nucleus. Concentration 0.4 mg/mL Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. Purification Method Affinity purification Research Areas Cancer,  Cell Biology,  Epigenetics and Nuclear Signaling,  Metabolism Conjugation Unconjugated Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. Related Reagents Applications Recommended Dilution IHC 1:50-1:200 Background Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.